Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells

S Ekmekcioglu, C Chattopadhyay*, U Akar*… - Nutrition and …, 2011 - Taylor & Francis
Melanoma is the most aggressive form of skin cancer. The rising incidence of melanoma
and its poor prognosis in advanced stages are compelling reasons to identify novel …

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

CB Lim, PY Fu, N Ky, HS Zhu, XL Feng, J Li… - … and alternative medicine, 2012 - Springer
Background Numerous studies have demonstrated that autophagy plays a vital role in
maintaining cellular homeostasis. Interestingly, several anticancer agents were found to …

Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells

C Braicu, O Zanoaga, AA Zimta, AB Tigu… - Seminars in Cancer …, 2022 - Elsevier
Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today's society, the study of compounds isolated from natural sources …

Targeting proteolysis with cyanogenic glycoside amygdalin induces apoptosis in breast cancer cells

V Cecarini, S Selmi, M Cuccioloni, C Gong, L Bonfili… - Molecules, 2022 - mdpi.com
Background: Breast cancer is the most diagnosed cancer among women, and its incidence
and mortality are rapidly growing worldwide. In this regard, plant-derived natural compounds …

[PDF][PDF] Targeting cancer through autophagy with Β‐Elemene and Puerarin

P Su, B Ahmad, H Ullah, B Hussain… - American Journal of …, 2020 - researchgate.net
Cancer remains the second foremost cause of mortality around the world; therefore
immediate development of highly effective and safe therapy is important. Different therapies …

Marrubium vulgare ethanolic extract induces proliferation block, apoptosis, and cytoprotective autophagy in cancer cells in vitro

V Paunovic, M Kosic, S Djordjevic, A Zugic… - Cellular and Molecular …, 2016 - cellmolbiol.org
Marrubium vulgare is a European medicinal plant with numerous beneficial effects on
human health. The aim of the study was to isolate the plant ethanolic extract (MVE) and to …

Quercetin Induces Mitochondrial Apoptosis and Downregulates Ganglioside GD3 Expression in Melanoma Cells

SY Seo, WS Ju, K Kim, J Kim, JO Yu, JS Ryu… - International Journal of …, 2024 - mdpi.com
Malignant melanoma represents a form of skin cancer characterized by a bleak prognosis
and heightened resistance to traditional therapies. Quercetin has demonstrated notable anti …

Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis-and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma

Y Liu, L Wang, T Huang, Y Li… - Journal of Agricultural and …, 2024 - ACS Publications
Chrysoeriol, a natural flavonoid, has shown potential in inhibiting melanoma. However, the
detailed molecular mechanisms of its action still need to be clarified. In this study …

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis

J Liu, Y Zhang, J Qu, L Xu, K Hou, J Zhang, X Qu, Y Liu - BMC cancer, 2011 - Springer
Background β-Elemene, a compound found in an herb used in traditional Chinese medicine,
has shown promising anti-cancer effects against a broad spectrum of tumors. The …

Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability

JJ Junco, A Mancha-Ramirez, G Malik, SJ Wei… - Melanoma …, 2015 - journals.lww.com
Malignant melanoma is associated with a 5-year survival rate of less than 20% once
metastasized. Malignant melanoma cells exhibit increased levels of autophagy, a process of …