Structural biology of the Gram-negative bacterial conjugation systems

A Ilangovan, S Connery, G Waksman - Trends in microbiology, 2015 - cell.com
Conjugation, the process by which plasmid DNA is transferred from one bacterium to
another, is mediated by type IV secretion systems (T4SSs). T4SSs are versatile systems that …

[HTML][HTML] Mechanism and structure of the bacterial type IV secretion systems

PJ Christie, N Whitaker, C González-Rivera - Biochimica et Biophysica Acta …, 2014 - Elsevier
The bacterial type IV secretion systems (T4SSs) translocate DNA and protein substrates to
bacterial or eukaryotic target cells generally by a mechanism dependent on direct cell-to-cell …

Translocation through the conjugative type IV secretion system requires unfolding of its protein substrate

M Trokter, G Waksman - Journal of bacteriology, 2018 - Am Soc Microbiol
Bacterial conjugation, a mechanism of horizontal gene transfer, is the major means by which
antibiotic resistance spreads among bacteria (1, 2). Conjugative plasmids are transferred …

Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …

Biological and structural diversity of type IV secretion systems

YG Li, B Hu, PJ Christie - Microbiology spectrum, 2019 - Am Soc Microbiol
The bacterial type IV secretion systems (T4SSs) are a functionally diverse superfamily of
secretion systems found in many species of bacteria. Collectively, the T4SSs translocate …

Structural biology of bacterial type IV secretion systems

V Chandran Darbari, G Waksman - Annual review of …, 2015 - annualreviews.org
Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-
negative and gram-positive bacteria and in some archaea. These systems transport a …

Structure and role of coupling proteins in conjugal DNA transfer

FX Gomis-Rüth, F de la Cruz, M Coll - Research in microbiology, 2002 - Elsevier
Type IV secretory systems are transmembrane bacterial multiprotein complexes. They are
pivotal for conjugation, bacterial-induced plant tumour formation, toxin secretion and …

Microreview: type IV secretion systems: versatility and diversity in function

K Wallden, A Rivera‐Calzada… - Cellular …, 2010 - Wiley Online Library
Type IV secretion systems (T4SSs) are large protein complexes which traverse the cell
envelope of many bacteria. They contain a channel through which proteins or protein–DNA …

From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective

G Waksman - EMBO reports, 2019 - embopress.org
Conjugation is the process by which bacteria exchange genetic materials in a unidirectional
manner from a donor cell to a recipient cell. The discovery of conjugation signalled the dawn …

Unveiling molecular scaffolds of the type IV secretion system

HJ Yeo, G Waksman - Journal of bacteriology, 2004 - Am Soc Microbiol
In gram-negative bacteria, secretion of macromolecules across the two membranes takes
place using diverse macromolecular transport assemblies, from simple one-component …