The kidney has extraordinary metabolic demands to sustain the active transport of solutes
that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those …

Although diabetic kidney disease (DKD) is the most common cause of end-stage kidney
disease worldwide, the pathogenic mechanisms are poorly understood. There is increasing …

Cellular metabolic changes during chronic kidney disease (CKD) may induce higher
production of oxygen radicals that play a significant role in the progression of renal damage …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions
such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell …

Acute kidney injury (AKI) remains a major problem in critically unwell children and young
adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a …

Objectives: To test whether mitochondrial transplantation (MITO) mitigates damage in 2
models of acute kidney injury (AKI). Background: MITO is a process where exogenous …

Sepsis is a dysregulated response to severe infection characterized by life-threatening
organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the …

Diabetic nephropathy (DN) is a progressive microvascular complication arising from
diabetes. Within the kidney, the glomeruli, tubules, vessels and interstitium are disrupted …

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …