Neurotrophin-4 promotes the specification of trophectoderm lineage after parthenogenetic activation and enhances porcine early embryonic development

M Kim, J Lee, L Cai, H Choi, D Oh, A Jawad… - Frontiers in Cell and …, 2023 - frontiersin.org
Neurotrophin-4 (NT-4), a neurotrophic factor, appears to affect early embryonic development
because it is secreted not only by neurons but also by oviductal and uterine epithelial cells …

Beneficial Effects of Neurotrophin-4 Supplementation During in vitro Maturation of Porcine Cumulus-Oocyte Complexes and Subsequent Embryonic Development …

M Kim, SU Hwang, JD Yoon, J Lee, E Kim… - Frontiers in Veterinary …, 2021 - frontiersin.org
Neurotrophin-4 (NT-4) is a neurotrophic factor that plays an important role in follicular
development and oocyte maturation. However, it is not yet known whether NT-4 is related to …

Physiological and Functional Roles of Neurotrophin-4 During In Vitro Maturation of Porcine Cumulus–Oocyte Complexes

M Kim, SU Hwang, JD Yoon, J Lee, E Kim… - Frontiers in Cell and …, 2022 - frontiersin.org
Neurotrophin-4 (NT-4), a granulosa cell-derived factor and a member of the neurotrophin
family, is known to promote follicular development and oocyte maturation in mammals …

CHIR99021 and rpIL6 promote porcine parthenogenetic embryo development and blastocyst quality

SY Yin, BM Sun, T Xu, X Liu, LJ Huo, X Zhang, J Zhou… - Theriogenology, 2020 - Elsevier
Signaling pathways and transcription factors are involved in porcine embryonic
development. Here, we demonstrate that glycogen synthase kinase-3 (GSK3) inhibitor …

Inhibition of FGF signalling pathway augments the expression of pluripotency and trophoblast lineage marker genes in porcine parthenogenetic blastocyst

LY Li, MM Li, SF Yang, J Zhang, Z Li… - … in Domestic Animals, 2016 - Wiley Online Library
Contents The consistent failure to isolate bona fide pluripotent cell lines from livestock
indicates that the underlying mechanisms of early lineage specification are poorly defined …

Tyrosine kinase A, C and fibroblast growth factor-2 receptors in bovine embryos cultured in vitro

M Munoz, A Rodriguez, C Diez, JN Caamaño… - Theriogenology, 2009 - Elsevier
Neurotrophins and basic fibroblast growth factor are ligands of tyrosine kinase receptors,
though they bind to different tyrosine kinase receptor classes. Neurotrophins bind to receptor …

Kinetin enhances in vitro development of parthenogenetic and nuclear transfer porcine embryos

C Won, SK Park, SG Cho, BM Min… - Molecular Reproduction …, 2008 - Wiley Online Library
Culture conditions affect the development of mammalian embryos in vitro. Kinetin belongs to
the family of N6‐substituted adenine derivates and promotes cell division, synthesis of DNA …

Inhibition of MEK1/2 and GSK3 (2i system) affects blastocyst quality and early differentiation of porcine parthenotes

J Kwon, YH Li, YJ Jo, YJ Oh, S Namgoong, NH Kim - PeerJ, 2019 - peerj.com
Inhibition of both MEK1/2 and glycogen synthase kinase-3 (GSK3; 2i system) facilitates the
maintenance of naïve stemness for embryonic stem cells in various mammalian species …

Aberrant expression of developmentally important signaling molecules in cloned porcine extraembryonic tissues

JI Chae, K Yu, SK Cho, JH Kim, DB Koo, KK Lee… - …, 2008 - Wiley Online Library
Early embryonic losses are common in cloned embryos in the current cloning system.
However, the reasons for embryonic losses in early developmental stages of cloned …

Combined chaetocin/trichostatin A treatment improves the epigenetic modification and developmental competence of porcine somatic cell nuclear transfer embryos

PS Jeong, HJ Yang, SH Park, MA Gwon… - Frontiers in Cell and …, 2021 - frontiersin.org
Developmental defects in somatic cell nuclear transfer (SCNT) embryos are principally
attributable to incomplete epigenetic reprogramming. Small-molecule inhibitors such as …