The endoplasmic reticulum is the most abundant membrane organelle in eukaryotic cells. It
is an important site of membrane and secretory protein folding and glycolipid synthesis and …

The underlying causes of nonalcoholic fatty liver disease are unclear, although recent
evidence has implicated the endoplasmic reticulum in both the development of steatosis and …

Manipulating endoplasmic reticulum stress pathway yields encouraging results for the
treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is …

Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often
causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded …

In many physiopathological conditions, the cell controls its proper dysfunction via activation
of the unfolded protein response to restore efficient protein synthesis and folding in the …

The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …

The underlying causes of nonalcoholic fatty liver disease (NAFLD) are unclear, although
recent evidence has implicated the endoplasmic reticulum (ER) in both the development of …

The endoplasmic reticulum (ER) is most notable for its central roles in calcium ion storage,
lipid biosynthesis, and protein sorting and processing. By virtue of its extensive membrane …

Obesity challenges lipid and carbohydrate metabolism. The resulting glucolipotoxicity
causes endoplasmic reticulum (ER) dysfunction, provoking the accumulation of immature …

Reactive oxygen species (ROS) are produced during normal physiologic processes with the
consumption of oxygen. While ROS play signaling roles, when they are produced in excess …