Nonalcoholic fatty liver disease (NAFLD) has emerged as a common public health problem
in recent decades. However, the underlying mechanisms leading to the development of …

As an adaptive response to the overloading with misfolded proteins in the endoplasmic
reticulum (ER), ER stress plays critical roles in maintaining protein homeostasis in the …

Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic
fibrosis, but the role it plays varies depending on the cause and progression of the disease …

Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have
been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this …

The endoplasmic reticulum (ER) is an essential organelle for protein and lipid synthesis in
hepatocytes. ER homeostasis is vital to maintain normal hepatocyte physiology. Perturbed …

Endoplasmic reticulum (ER) stress could participate in high-fat diet (HFD)-induced hepatic
steatosis. The current study aims to investigate the role of ER stress as well as inflammation …

The endoplasmic reticulum (ER) is an organelle important for protein synthesis and folding,
lipid synthesis and Ca 2+ homoeostasis. Consequently, ER stress or dysfunction affects …

Impaired regulation of hepatic glucose production is a characteristic feature of the metabolic
syndrome, a cluster of diseases that includes obesity, insulin resistance, type 2 diabetes …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …