The endoplasmic reticulum (ER) has emerged as a key to understanding the development
and consequences of hepatic fat accumulation in nonalcoholic fatty liver disease (NAFLD) …

We analyse how chronic overfeeding, by increasing circulating fatty acids, might lead to
inflammation, insulin resistance (IR) and injury in the liver. Chronic overfeeding causes an …

Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling
network that coordinates adaptive and apoptotic responses. There is accumulating evidence …

The folding process is an important step in protein synthesis for the functional shape or
conformation of the protein. The endoplasmic reticulum (ER) is the main organelle for the …

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to …

Endoplasmic reticulum (ER) stress functions as a protein folding and quality control
mechanism to maintain cell homeostasis. Emerging evidence indicates that ER stress is also …

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium
storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for …

Endoplasmic Reticulum (ER) stress refers to a condition of accumulation of unfolded or
misfolded proteins in the ER lumen. A variety of biochemical stimuli or pathophysiologic …

Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis
cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response …

Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …