The allelic frequencies of TaqI, PstI, and variable number of tandem repeat (VNTR)
polymorphisms of the IL-1β, IL-1 receptor (IL-1Re), and IL-1 receptor antagonist (IL-1Ra) …

Background Interleukin 1 (IL‐1) and its physiological antagonist interleukin‐1 receptor
antagonist (IL‐1ra) play a crucial role in the pathogenesis of inflammatory bowel disease …

Background—An imbalance between the proinflammatory cytokine interleukin 1β (IL-1β)
and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) has been postulated as …

Background: There is growing evidence of the importance of genetic predisposition and the
activation of the mucosal immune system in the pathogenesis of inflammatory bowel …

There is evidence of a disbalance in the inflammatory regulation of patients with
inflammatory bowel diseases (IBD). Interleukin-1β plays an important role in the pro …

Genetic linkage analysis in families with multiple cases of inflammatory bowel disease (IBD)
has mapped a gene which confers susceptibility to IBD to the pericentromeric region of …

Recent reports have shown that allele 2 of the IL-1 receptor antagonist (IL-1Ra) gene is over-
represented in ulcerative colitis (UC). Healthy individuals carrying allele 2 of this gene have …

Objective: Genetic susceptibility to inflammatory bowel disease is well recognized. There is
also increasing evidence for the activation of the mucosal immune system and the …

Although the importance of genetic susceptibility to IBD has been established by
epidemiological studies, the genes involved remain poorly characterized. Important …

The IL-6 gene maps to an area of chromosome 7 known to be significant for susceptibility to
inflammatory bowel disease. The functional effects of interleukin-6 (IL-6) polymorphisms in …