Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Osteosarcoma is the most common primary malignant bone tumor in children. Validated
biological markers for disease prognosis available at diagnosis are lacking. No genome …

Genetic and epigenetic changes contribute to deregulation of gene expression and
development of human cancer. Changes in DNA methylation are key epigenetic factors …

The identification of optimal methylation biomarkers to achieve maximum diagnostic ability
remains a challenge. The present study aimed to elucidate the potential molecular …

Chondrosarcoma (CS) is the second most common primary malignant bone tumor. Unlike
other bone tumors, CS is highly resistant to conventional chemotherapy and radiotherapy …

Background Osteosarcomas are the most common non-haematological primary malignant
tumours of bone, and all conventional osteosarcomas are high-grade tumours showing …

BACKGROUND Osteosarcoma is the most common solid malignant diseases of childhood,
occurring in approximately 6 children per million annually; however, to the authors' …

Osteosarcoma (OS) patients with metastasis or recurrent tumors still suffer from poor
prognosis. Studies have indicated the efficacy of DNA demethylation therapy for OS, but the …

Background The study aimed to analyze aberrantly methylated genes, relevant pathways
and transcription factors (TFs) in osteosarcoma (OS) development. Methods Based on the …

Osteosarcoma (OS) is the eighth most common form of childhood and adolescence cancer.
Approximately 10%–20% of patients present metastatic disease at diagnosis and the 5-year …