Vectors based on adeno-associated virus (AAV) have recently been used in phase I clinical
trials for the treatment of neurological disorders, such as Parkinson's and Canavan's …

Over the last few years, a large number of preclinical and clinical studies have demonstrated
the potential of gene therapy applications using adeno‐associated viral (AAV) vectors. Gene …

Transgenic strategies are useful for funcional studies and they may also lead to novel
therapies. Controlling transgene expression in defined cell populations over time is …

Gene therapy is a novel method under investigation for the treatment of neurological
disorders. Considerable interest has focused on the possibility of using viral vectors to …

One of the most promising virus vectors being studied for gene therapy is derived from
adeno-associated virus (AAV), a single-stranded DNA virus that is ubiquitous to humans but …

Gene therapy vectors based on the adeno-associated virus (AAV) are being developed for a
widening variety of therapeutic applications. Enthusiasm for AAV is due, not only to the …

Publisher Summary This chapter focuses on the biology and applications of adeno-
associated virus (AAV) vectors to the study and treatment of the fully developed, adult …

Adeno-associated virus (AAV) shows significant potential as a gene delivery system.
Although it is ubiquitous in its distribution, with approximately 85% of the adult population in …

Adeno‐associated virus (AAV) vectors are able to transduce CNS cells in vitro and in vivo for
extended periods of time without immune complications. The ability to efficiently deliver …

Gene therapy remains an attractive form of treatment for a variety of diseases, both inherited
and acquired. Recent experience in clinical gene therapy has highlighted important safety …