[PDF][PDF] Enhancing natural killer cell-mediated cancer immunotherapy by the biological macromolecule nocardia rubra cell-wall skeleton

J Wu, B He, M Miao, X Han, H Dai, H Dou… - Pathology and …, 2022 - por-journal.com
The biological macromolecule Nocardia rubra cell-wall skeleton (Nr-CWS) has
wellestablished immune-stimulating and anti-tumor activities. However, the role of Nr-CWS …

The biological macromolecule Nocardia rubra cell‐wall skeleton as an avenue for cell‐based immunotherapy

Y Meng, J Sun, X Wang, Y Ma, C Kong… - Journal of Cellular …, 2019 - Wiley Online Library
Promoting the antitumor effects of cell‐based immunotherapy for clinical application remains
a difficult challenge. Nocardia rubra cell‐wall skeleton (N‐CWS) is an immunotherapeutic …

Augmentative effect of Nocardia rubra cell-wall skeleton (N-CWS) on lymphokine-activated killer (LAK) cell induction

S Yokota, T Shirasaka, H Nishikawa, S Hosoe… - Cancer Immunology …, 1988 - Springer
The present study elucidated that N-CWS augments the cytolytic activity against 3LL tumor
cells of LAK cells from N-CWS-immunized mice administered ip with rIL-2. This …

Th1 immune maturation effects of Nocardia rubra cell-wall skeleton via PI3K/Akt/PAX8 regulatory axis

M Zhou, S Zhou, K Han, J Zhang, Q Chen… - Science …, 2022 - journals.sagepub.com
Nocardia rubra cell-wall skeleton (Nr-CWS) is reported as an external immunotherapeutic
enhancer with the advantage of antitumor effect on human cancers. However, the immune …

Effect of Nocardia rubra Cell Wall Skeleton on T-Cell-mediated Cytotoxicity in Mice Bearing Syngeneic Sarcoma

I Kawase, M Uemiya, T Yoshimoto, T Ogura, F Hirao… - Cancer Research, 1981 - AACR
Cell-mediated cytotoxicity against syngeneic MC104 fibrosarcoma cells was detected in
C57BL/6N mice 7 days after tumor inoculation in the hind foot. This cytotoxicity was …

Nocardia rubra cell‐wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells

S Zhang, H Wang, Y Liu, T Tao, Z Zeng… - Cancer …, 2022 - Wiley Online Library
Background As an immune enhancer, Nocardia rubra cell‐wall skeleton (Nr‐CWS) has
been used to treat persistent human papillomavirus infection and cervical precancerous …

[HTML][HTML] Proteome analysis of human natural killer cell derived extracellular vesicles for identification of anticancer effectors

JW Choi, S Lim, JH Kang, SH Hwang, KC Hwang… - Molecules, 2020 - mdpi.com
Cancer immunotherapy is a clinically validated therapeutic modality for cancer and has
been rapidly advancing in recent years. Adoptive transfer of immune cells such as T cells …

Nocardia rubra cell-wall skeleton promotes CD4+ T cell activation and drives Th1 immune response

G Wang, J Wu, M Miao, H Dou, N Nan, M Shi… - International journal of …, 2017 - Elsevier
Several lines of evidences have shown that Nocardia rubra cell wall skeleton (Nr-CWS) has
immunoregulatory and anti-tumor activities. However, there is no information about the effect …

[HTML][HTML] The Nocardia Rubra Cell Wall skeleton regulates macrophages and promotes wound healing

K Hu, Y Xu, X Li, P Du, Y Lu, G Lyu - Current Issues in Molecular Biology, 2022 - mdpi.com
The Nocardia rubra cell wall skeleton (Nr-CWS) is an immunomodulator used clinically for
its ability to modulate the body's immune function. Macrophages are an important hub of the …

[HTML][HTML] NK cell phenotypic modulation in lung cancer environment

S Jin, Y Deng, JW Hao, Y Li, B Liu, Y Yu, FD Shi… - PloS one, 2014 - journals.plos.org
Background Nature killer (NK) cells play an important role in anti-tumor immunotherapy. But
it indicated that tumor cells impacted possibly on NK cell normal functions through some …