Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress

M Tang, H Huang, S Li, M Zhou, Z Liu, R Huang… - Translational …, 2019 - nature.com
Chronic stressful occurrences are documented as a vital cause of both depression and
anxiety disorders. However, the stress-induced molecular mechanisms underlying the …

Chronic mild stress-induced protein dysregulations correlated with susceptibility and resiliency to depression or anxiety revealed by quantitative proteomics of the rat …

W Liao, Y Liu, L Wang, X Cai, H Xie, F Yi… - Translational …, 2021 - nature.com
Chronic stress is a significant risk factor for depression as well as anxiety disorders. Yet, the
stress-induced specific and common molecular dysregulations of these disorders have not …

Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression

K Henningsen, J Palmfeldt, S Christiansen… - Molecular & Cellular …, 2012 - ASBMB
Susceptibility to stress plays a crucial role in the development of psychiatric disorders such
as unipolar depression and post-traumatic stress disorder. In the present study the chronic …

Integrated metabolomics and proteomics analysis of hippocampus in a rat model of depression

Y Zhang, S Yuan, J Pu, L Yang, X Zhou, L Liu, X Jiang… - Neuroscience, 2018 - Elsevier
Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates
of suicide and disability. However, the underlying pathogenesis of MDD is complicated and …

Proteomic analysis of rat hippocampus after repeated psychosocial stress

L Carboni, C Piubelli, C Pozzato, H Astner, R Arban… - Neuroscience, 2006 - Elsevier
Since stress plays a role in the onset and physiopathology of psychiatric diseases, animal
models of chronic stress may offer insights into pathways operating in mood disorders. The …

Protein biomarkers of susceptibility and resilience to stress in a rat model of depression

J Palmfeldt, K Henningsen, SA Eriksen… - Molecular and Cellular …, 2016 - Elsevier
The molecular etiologies of psychological stress and major depressive disorder (MDD) are
highly complex and many brain regions are involved. The prefrontal cortex (PFC) has …

AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models

X Li, T Teng, W Yan, L Fan, X Liu, G Clarke… - Translational …, 2023 - nature.com
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The
pathogenesis of MDD remained unclear, and it may be associated with exposure to different …

Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression

L Liu, X Zhou, Y Zhang, J Pu, L Yang, S Yuan… - Translational …, 2018 - nature.com
Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the
underlying molecular mechanisms remain largely unknown. However, many studies have …

[HTML][HTML] Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression

H Cao, C Zuo, Y Huang, L Zhu, J Zhao, Y Yang… - Behavioural Brain …, 2021 - Elsevier
Neuronal loss has been identified in depression, but its mechanisms are not fully
understood. Proteomic analyses provide a novel insight to explore the potential mechanisms …

The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers

A Larosa, TP Wong - Progress in Neuro-Psychopharmacology and …, 2022 - Elsevier
Understanding the individual variability that comes with the likelihood of developing stress-
related psychopathologies is of paramount importance when addressing mechanisms of …