Leptin is a well-known hunger-sensing peptide hormone. The role of leptin in weight gain
and metabolic homeostasis has been explored for the past two decades. In this review, we …

It is well established that decreases in plasma leptin levels, as with fasting, signal starvation
and elicit appropriate physiological responses, such as increasing the drive to eat and …

Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis.
Impairment of leptin signaling is closely involved in the pathogenesis of obesity and …

Leptin (from the Greek word “lepto''meaning “thin”) is a 167-amino acid peptide hormone
encoded by the obesity (ob) gene and secreted by white adipocytes. Blood leptin …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass.
It decreases food intake and increases energy expenditure by affecting the balance between …

Introduction: Leptin is a hormone with a key role in food intake and body weight
homeostasis. Congenital leptin deficiency (CLD) is a rare disease that causes hyperphagia …

Leptin is an endogenous protein having 167 amino acids and is derived from adipocytes. It
has tertiary structure that resembles with that of the pro‐inflammatory cytokines family. The …

Since its discovery as an adipocyte-secreted hormone, leptin has been found to impact food
intake, energy homeostasis, and metabolism through its effects on the central nervous …