Apolipoprotein (a) kringle IV repeat number predicts risk for coronary heart disease

HG Kraft, A Lingenhel, S Kochl… - … , and vascular biology, 1996 - Am Heart Assoc
A high plasma concentration of lipoprotein (a)[Lp (a)] has been suggested as a risk factor for
coronary heart disease (CHD), but some recent prospective studies have questioned the …

Impact of lipoprotein (a) levels and apolipoprotein (a) isoform size on risk of coronary heart disease

JC Hopewell, U Seedorf, M Farrall… - Journal of internal …, 2014 - Wiley Online Library
Objectives Observational and genetic studies have shown that lipoprotein (a)[L p (a)] levels
and apolipoprotein (a)[apo (a)] isoform size are both associated with coronary heart disease …

A common nonsense mutation in the repetitive Kringle IV‐2 domain of human apolipoprotein (a) results in a truncated protein and low plasma Lp (a)

W Parson, HG Kraft, H Niederstätter… - Human …, 2004 - Wiley Online Library
LPA, the gene coding for apolipoprotein (a)[apo (a)], is the major determinant of lipoprotein
(a)[Lp (a)] plasma levels, which are associated with risk for coronary heart disease (CHD) …

Frequency distributions of apolipoprotein (a) kringle IV repeat alleles and their effects on lipoprotein (a) levels in Caucasian, Asian, and African populations: the …

HG Kraft, A Lingenhel, RWC Pang, R Delport… - European Journal of …, 1996 - nature.com
Abstract A size polymorphism (K IV VNTR) and largely unknown sequence variation in the
apolipoprotein (a)[apo (a)] gene on chromosome 6q26–q27 together determine most of the …

Association of polymorphisms of the apolipoprotein (a) gene with lipoprotein (a) levels and myocardial infarction

SR Holmer, C Hengstenberg, HG Kraft, B Mayer… - Circulation, 2003 - Am Heart Assoc
Background—Serum lipoprotein (a)[Lp (a)] concentration is largely determined by variability
at the apolipoprotein (a) gene locus. Most prominent effects relate to polymorphisms in the …

The apolipoprotein (a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms

YY Hoek, ME Wittekoek, U Beisiegel… - Human molecular …, 1993 - academic.oup.com
Elevated levels of plasma lipoprotein (a)[Lp (a)] have been correlated with the development
of atherosclerosis in human populations. Apolipoprotein (a)[apo (a); the distinguishing …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

Single nucleotide polymorphisms in exons of the apo (a) kringles IV types 6 to 10 domain affect Lp (a) plasma concentrations and have different patterns in Africans …

M Ogorelkova, HG Kraft, C Ehnholm… - Human molecular …, 2001 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a complex of apolipoprotein (a)[apo (a)] and low-density
lipoprotein which is associated with atherothrombotic disease. Lp (a) plasma levels are …

Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma

V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …