Recent data suggest that the chemokine receptor CXCR3 is functionally involved in
fibroproliferative disorders, including liver fibrosis. Neoangiogenesis is an important …

Portal fibroblasts (PF) are fibrogenic liver cells distinct from hepatic stellate cells (HSC).
Recent evidence suggests that PF may be important mediators of biliary fibrosis and …

Background/Aims: Liver fibrosis is a complex process of tissue remodeling in response to
injury. Hepatic macrophages have been identified as a key player in this process. As the …

Background & aims: The chemokines CCL19 and CCL21 bind CCR7, which is involved in
the organization of secondary lymphoid tissue and is expressed during chronic tissue …

Liver fibrosis is a major cause of morbidity and mortality worldwide. Platelets are involved in
liver damage, but the underlying molecular mechanisms remain elusive. Here, we …

Background & Aims Macrophages contribute to liver disease, but their role in cholestatic
liver injury, including primary sclerosing cholangitis (PSC), is unclear. We tested the …

BACKGROUND & AIMS: Fibrosis is the hallmark of chronic liver diseases, yet many aspects
of its mechanism remain to be defined. Chemokines are ubiquitous chemotactic molecules …

In addition to liver‐resident Kupffer cells, infiltrating immune cells have recently been linked
to the development of liver fibrosis. Blood monocytes are circulating precursors of tissue …

Following liver injury, hepatic stellate cells (HSC) undergo proliferation and migrate into
damaged areas in response to chemotactic factors. HSC have been shown to regulate …

Human hepatocellular carcinoma (HCC) is an inflammation‐induced cancer, which is the
third‐leading cause of cancer mortality worldwide. We investigated the role of the …