CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3α might be involved in the amplification of local necroinflammatory response in the liver
Y Shimizu, H Murata, Y Kashii, K Hirano, H Kunitani… - Hepatology, 2001 - Elsevier
It is not fully understood how antigen-specific or-nonspecific T cells migrate into the liver in
various liver diseases. Macrophage inflammatory protein (MIP)-3α is a chemokine that is …
various liver diseases. Macrophage inflammatory protein (MIP)-3α is a chemokine that is …
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
Cathepsins have been best characterized in tumorigenesis and cell death and implicated in
liver fibrosis; however, whether cathepsins directly regulate hepatic stellate cell (HSC) …
liver fibrosis; however, whether cathepsins directly regulate hepatic stellate cell (HSC) …
Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases
Background: Chemokines are chemotactic mediators that are implicated in liver diseases. In
viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in …
viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in …
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
K Miura, L Yang, N van Rooijen… - American Journal of …, 2012 - journals.physiology.org
Inflammatory cell infiltration in the liver is a hallmark of nonalcoholic steatohepatitis (NASH).
The chemokine-chemokine receptor interaction induces inflammatory cell recruitment. CC …
The chemokine-chemokine receptor interaction induces inflammatory cell recruitment. CC …
[PDF][PDF] Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis
O Krenkel, T Puengel, O Govaere, AT Abdallah… - …, 2018 - Wiley Online Library
Macrophages are key regulators of liver fibrosis progression and regression in nonalcoholic
steatohepatitis (NASH). Liver macrophages comprise resident phagocytes, Kupffer cells …
steatohepatitis (NASH). Liver macrophages comprise resident phagocytes, Kupffer cells …
Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression
BD Radbill, R Gupta, MCM Ramirez, A DiFeo… - Digestive diseases and …, 2011 - Springer
Abstract Background and Aims Matrix metalloproteinase-2 (MMP-2), a type IV collagenase
secreted by activated hepatic stellate cells (HSCs), is upregulated in chronic liver disease …
secreted by activated hepatic stellate cells (HSCs), is upregulated in chronic liver disease …
[HTML][HTML] Fibrogenic signaling is suppressed in hepatic stellate cells through targeting of connective tissue growth factor (CCN2) by cellular or exosomal microRNA …
L Chen, R Chen, VM Velazquez… - The American journal of …, 2016 - Elsevier
Pathways of liver fibrosis are controlled by connective tissue growth factor (CCN2). In this
study, CCN2 was identified as a target of miR-199a-5p, which was principally expressed in …
study, CCN2 was identified as a target of miR-199a-5p, which was principally expressed in …
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
Background In the setting of chronic liver injury in humans, epidermal growth factor (EGF)
and EGF receptor (EGFR) are up-regulated and have been proposed to have vital roles in …
and EGF receptor (EGFR) are up-regulated and have been proposed to have vital roles in …
Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats
SW Luckey, DR Petersen - Experimental and molecular pathology, 2001 - Elsevier
Kupffer cells are involved in the pathogenesis of chemically mediated liver injury through
release of biologically active mediators that promote the pathogenic process. The purpose of …
release of biologically active mediators that promote the pathogenic process. The purpose of …