Background The polygenic risk score (PRS) is derived from single nucleotide
polymorphisms (SNPs) including those that are genome-wide significant and also including …

Background Genome-wide association studies (GWAS) have identified several loci
associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis …

Studying the phenotypic manifestations of increased genetic liability for schizophrenia can
increase our understanding of this disorder. Specifically, information from alleles identified in …

Technological progress is reshaping the nature versus nurture debate of disease causation.
Fifty years ago, psychiatrists used to argue over whether schizophrenia was caused by a …

Genome‐wide association studies (GWAS) of schizophrenia have yielded more than 100
common susceptibility variants, and strongly support a substantial polygenic contribution of …

Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …

Large numbers of genetic loci have been identified that are known to contain common risk
alleles for schizophrenia, but linking associated alleles to specific risk genes remains …

It is widely thought that alleles that influence susceptibility to common diseases, including
schizophrenia, will frequently do so through effects on gene expression. As only a small …

Background Schizophrenia is a heritable psychiatric disorder with a polygenic architecture.
Genome-wide association studies have reported that an increasing number of risk …

Background The polygenic risk score (PRS) for schizophrenia, derived from very large
numbers of weakly associated genetic markers, has been repeatedly shown to be robustly …