The role of fibroblast growth factors in tumor growth
M Korc, RE Friesel - Current cancer drug targets, 2009 - ingentaconnect.com
Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …
Fibroblast growth factors and their receptors in cancer
J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …
regulating cell proliferation, survival, migration and differentiation during development and …
Fibroblast growth factor signalling: from development to cancer
N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …
functions, regulating cellular proliferation, survival, migration and differentiation. Although …
Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis
Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival,
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …
The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis
Introduction: Fibroblast growth factors (FGFs) are endowed with a potent pro-angiogenic
activity. Activation of the FGF/FGF receptor (FGFR) system occurs in a variety of human …
activity. Activation of the FGF/FGF receptor (FGFR) system occurs in a variety of human …
[HTML][HTML] Mechanisms of FGFR-mediated carcinogenesis
I Ahmad, T Iwata, HY Leung - … et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated
signalling in carcinogenesis are considered and relevant underlying mechanisms …
signalling in carcinogenesis are considered and relevant underlying mechanisms …
De-regulated FGF receptors as therapeutic targets in cancer
V Knights, SJ Cook - Pharmacology & therapeutics, 2010 - Elsevier
Fibroblast growth factors (FGFs) acting through their cognate receptors (FGFRs) play vital
roles in development and de-regulation of FGF/FGFR signalling is associated with many …
roles in development and de-regulation of FGF/FGFR signalling is associated with many …
Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer
AN Brooks, E Kilgour, PD Smith - Clinical cancer research, 2012 - AACR
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …
an important role in normal organ, vascular, and skeletal development. Deregulation of …
[HTML][HTML] Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …
Mammalian FGF family members participate in multiple signaling pathways by binding to …
Fibroblast growth factor signaling in tumorigenesis
R Grose, C Dickson - Cytokine & growth factor reviews, 2005 - Elsevier
Fibroblast growth factors and their signaling receptors have been associated with multiple
biological activities, including proliferation, differentiation and motility. Consequently, they …
biological activities, including proliferation, differentiation and motility. Consequently, they …