The role of fibroblast growth factors in tumor growth

M Korc, RE Friesel - Current cancer drug targets, 2009 - ingentaconnect.com
Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …

Fibroblast growth factors and their receptors in cancer

J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

Fibroblast growth factor signalling: from development to cancer

N Turner, R Grose - Nature Reviews Cancer, 2010 - nature.com
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological
functions, regulating cellular proliferation, survival, migration and differentiation. Although …

Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis

C Lieu, J Heymach, M Overman, H Tran, S Kopetz - Clinical cancer research, 2011 - AACR
Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival,
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …

The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis

R Ronca, A Giacomini, M Rusnati… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Fibroblast growth factors (FGFs) are endowed with a potent pro-angiogenic
activity. Activation of the FGF/FGF receptor (FGFR) system occurs in a variety of human …

[HTML][HTML] Mechanisms of FGFR-mediated carcinogenesis

I Ahmad, T Iwata, HY Leung - … et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated
signalling in carcinogenesis are considered and relevant underlying mechanisms …

De-regulated FGF receptors as therapeutic targets in cancer

V Knights, SJ Cook - Pharmacology & therapeutics, 2010 - Elsevier
Fibroblast growth factors (FGFs) acting through their cognate receptors (FGFRs) play vital
roles in development and de-regulation of FGF/FGFR signalling is associated with many …

Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer

AN Brooks, E Kilgour, PD Smith - Clinical cancer research, 2012 - AACR
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …

[HTML][HTML] Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies

MR Akl, P Nagpal, NM Ayoub, B Tai, SA Prabhu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …

Fibroblast growth factor signaling in tumorigenesis

R Grose, C Dickson - Cytokine & growth factor reviews, 2005 - Elsevier
Fibroblast growth factors and their signaling receptors have been associated with multiple
biological activities, including proliferation, differentiation and motility. Consequently, they …