Food is a powerful natural reinforcer that guides feeding decisions. The vagus nerve
conveys internal sensory information from the gut to the brain about nutritional value; …

Omnivores, including rodents and humans, compose their diets from a wide variety of
potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to …

The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

Survival requires the integration of external information and interoceptive cues to effectively
guide advantageous behaviors, particularly foraging and other behaviors that promote …

Energy homeostasis requires precise measurement of the quantity and quality of ingested
food. The vagus nerve innervates the gut and can detect diverse interoceptive cues, but the …

Hunger, driven by negative energy balance, elicits the search for and consumption of food.
While this response is in part mediated by neurons in the hypothalamus, the role of specific …

Overconsumption of palatable food may initiate neuroadaptive responses in brain reward
circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) …

A fundamental question of physiology is how gut-brain signaling stimulates appetite. While
many studies have emphasized the importance of vagal afferents to the brain in inducing …

Highlights•Discrete neuronal populations are sufficient for driving appetite and
satiety.•These neurons are regulated by sensory, hormonal, and exogenous …

Communication between the gut and brain is critical for homeostasis, but how this
communication is represented in the dynamics of feeding circuits is unknown. Here we …