Growth of Chlamydia pneumoniae Is Enhanced in Cells with Impaired Mitochondrial Function

N Käding, I Kaufhold, C Müller, M Szaszak… - Frontiers in Cellular …, 2017 - frontiersin.org
Effective growth and replication of obligate intracellular pathogens depend on host cell
metabolism. How this is connected to host cell mitochondrial function has not been studied …

Insights into mitochondrial dynamics in chlamydial infection

Y Yang, W Lei, L Zhao, Y Wen, Z Li - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Mitochondria are intracellular organelles that are instrumental in the creation of energy,
metabolism, apoptosis, and intrinsic immunity. Mitochondria exhibit an extraordinarily high …

Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation

Y Kurihara, R Itoh, A Shimizu, NF Walenna… - Cellular …, 2019 - Wiley Online Library
Chlamydia trachomatis is an obligate intracellular bacterium that scavenges host metabolic
products for its replication. Mitochondria are the power plants of eukaryotic cells and provide …

Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment

M Szaszák, K Shima, N Käding, M Hannus… - International Journal of …, 2013 - Elsevier
Chlamydia pneumoniae infections of the respiratory tract are common and are associated
with acute and chronic diseases such as community-acquired pneumonia (CAP) and …

Chlamydia trachomatis Requires Functional Host-Cell Mitochondria and NADPH Oxidase 4/p38MAPK Signaling for Growth in Normoxia

J Thapa, G Yoshiiri, K Ito, T Okubo… - Frontiers in cellular …, 2022 - frontiersin.org
Chlamydia trachomatis (Ct) is an intracellular energy-parasitic bacterium that requires ATP
derived from infected cells for its growth. Meanwhile, depending on the O2 concentration …

Chlamydia Infection Remodels Host Cell Mitochondria to Alter Energy Metabolism and Subvert Apoptosis

HC Cheong, S Sulaiman, CY Looi, LY Chang… - Microorganisms, 2023 - mdpi.com
Chlamydia infection represents an important cause for concern for public health worldwide.
Chlamydial infection of the genital tract in females is mostly asymptomatic at the early stage …

[HTML][HTML] Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission

SR Chowdhury, A Reimer, M Sharan… - The Journal of cell …, 2017 - ncbi.nlm.nih.gov
Obligate intracellular bacteria such as Chlamydia trachomatis depend on metabolites of the
host cell and thus protect their sole replication niche by interfering with the host cells' stress …

Regulation of the mitochondrion-fatty acid axis for the metabolic reprogramming of Chlamydia trachomatis during treatment with β-lactam antimicrobials

K Shima, I Kaufhold, T Eder, N Käding, N Schmidt… - MBio, 2021 - Am Soc Microbiol
Infection with the obligate intracellular bacterium Chlamydia trachomatis is the most
common bacterial sexually transmitted disease worldwide. Since no vaccine is available to …

Chlamydia trachomatis alters mitochondrial protein composition and secretes effector proteins that target mitochondria

Z Dimond, LD Bauler, Y Zhang, A Carmody… - Msphere, 2022 - Am Soc Microbiol
Mitochondria are critical cellular organelles that perform a wide variety of functions,
including energy production and immune regulation. To perform these functions …

Chlamydia pneumoniae Interferes with Macrophage Differentiation and Cell Cycle Regulation to Promote Its Replication

E Taavitsainen-Wahlroos, I Miettinen… - Cellular …, 2022 - Wiley Online Library
Chlamydia pneumoniae is a ubiquitous intracellular bacterium which infects humans via the
respiratory route. The tendency of C. pneumoniae to persist in monocytes and macrophages …