[HTML][HTML] Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays
WJ Xiong, LJ Hu, YC Jian, LJ Wang… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To identify differentially expressed genes in quiescent and activated hepatic stellate
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …
Wnt5a Promotes Cytokines Production and Cell Proliferation in Human Hepatic Stellate Cells Independent of Canonical Wnt Pathway.
S Dong, C Wu, J Hu, Q Wang, S Chen, W Zhirong… - Clinical …, 2015 - europepmc.org
Background Wnt5a is involved in the activation of human hepatic stellate cells (HSC) and
related with the occurrence of liver fibrosis. As the function and mechanism that Wnt5a …
related with the occurrence of liver fibrosis. As the function and mechanism that Wnt5a …
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
F Jiang, CJ Parsons, B Stefanovic - Journal of hepatology, 2006 - Elsevier
BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …
[HTML][HTML] Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12
Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …
morphological transformation into proliferative, contractile and ECM-producing …
Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
C Kordes, I Sawitza, D Häussinger - Biochemical and biophysical research …, 2008 - Elsevier
It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …
Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
JH Cheng, H She, YP Han, J Wang… - American Journal …, 2008 - journals.physiology.org
Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …
diminished adipogenic transcription. This study investigated whether Wnt signaling …
[HTML][HTML] Elimination of Wnt secretion from stellate cells is dispensable for zonation and development of liver fibrosis following hepatobiliary injury
R Zhang, AT Kikuchi, T Nakao, JO Russell… - Gene …, 2019 - ncbi.nlm.nih.gov
Alterations in the Wnt signaling pathway including those impacting hepatic stellate cells
(HSCs) have been implicated in liver fibrosis. In the current study, we first examined the …
(HSCs) have been implicated in liver fibrosis. In the current study, we first examined the …
Non-canonical Wnt predominates in activated rat hepatic stellate cells, influencing HSC survival and paracrine stimulation of Kupffer cells
The Wnt system is highly complex and is comprised of canonical and non-canonical
pathways leading to the activation of gene expression. Our aim was to examine changes in …
pathways leading to the activation of gene expression. Our aim was to examine changes in …
Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis
J Wang, L Li, L Li, Q Yan, J Li, T Xu - Gene, 2018 - Elsevier
Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …
Therefore, improving our understanding of the molecular pathways that are involved in these …
Secreted frizzled‐related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis
N Chatani, Y Kamada, T Kizu, S Ogura… - Liver …, 2015 - Wiley Online Library
Abstract Background & Aims Obesity‐related adipocytokine dysregulation is known to
accelerate liver fibrosis progression. Recently, a natural Wnt5a inhibitor, secreted frizzled …
accelerate liver fibrosis progression. Recently, a natural Wnt5a inhibitor, secreted frizzled …