Much of our understanding of molecular mecha-nisms of diseases has relied historically on
work performed in cancer cell lines. Although cancer-derived cell lines offer many …

The physiological characteristics of the gastrointestinal (GI) tract are diverse and include
rapid rates of epithelial turnover, complex nervous and immune systems, a thick mucus …

Microfluidic organ-on-a-chip models of human intestine have been developed and used to
study intestinal physiology and pathophysiology. In this article, we review this field and …

Organ-on-chip technology is a powerful tool for in vitro modeling. Combining it with
organoids overcomes lumen inaccessibility while preserving cellular diversity and function …

The intestinal epithelium has one of the highest turnover rates in the human body, which is
supported by intestinal stem cells. Culture models of intestinal physiology have been …

Background & Aims The mucus layer in the human colon protects against commensal
bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal …

The epithelium of the small intestine is composed of a single layer of epithelial cells lining
the villi that project into the lumen of the gut, and the crypts that descend into the underlying …

Canine intestines possess similarities in anatomy, microbiology, and physiology to those of
humans, and dogs naturally develop spontaneous intestinal disorders similar to humans …

Alterations in intestinal structure, mechanics and physiology underlie acute and chronic
intestinal conditions, many of which are influenced by dysregulation of microbiome …

The mammalian intestinal wall is one of the most complex organs in the body. A collection of
heterogeneous cell types including immune, neural, and epithelial, among others, creates a …