Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection Using Drosophila as a Model System

S Kaushik, R Kumar, P Kain - Journal of experimental …, 2018 - journals.sagepub.com
Taste modalities are conserved in insects and mammals. Sweet gustatory signals evoke
attractive behaviors while bitter gustatory information drive aversive behaviors. Salt (NaCl) is …

Salt sensation and regulation

S Puri, Y Lee - Metabolites, 2021 - mdpi.com
Taste sensation and regulation are highly conserved in insects and mammals. Research
conducted over recent decades has yielded major advances in our understanding of the …

Molecular and cellular mechanisms of salt taste

A Taruno, MD Gordon - Annual Review of Physiology, 2023 - annualreviews.org
Salt taste, the taste of sodium chloride (NaCl), is mechanistically one of the most complex
and puzzling among basic tastes. Sodium has essential functions in the body but causes …

A complex peripheral code for salt taste in Drosophila

AH Jaeger, M Stanley, ZF Weiss, PY Musso… - Elife, 2018 - elifesciences.org
Each taste modality is generally encoded by a single, molecularly defined, population of
sensory cells. However, salt stimulates multiple taste pathways in mammals and insects …

The role of the anion in salt (NaCl) detection by mouse taste buds

JK Roebber, SD Roper, N Chaudhari - Journal of Neuroscience, 2019 - Soc Neuroscience
How taste buds detect NaCl remains poorly understood. Among other problems, applying
taste-relevant concentrations of NaCl (50–500 mm) onto isolated taste buds or cells exposes …

An inhibitory mechanism for suppressing high salt intake in Drosophila

M Dey, A Ganguly, A Dahanukar - Chemical senses, 2023 - academic.oup.com
High concentrations of dietary salt are harmful to health. Like most animals, Drosophila
melanogaster are attracted to foods that have low concentrations of salt, but show strong …

A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster

J Sang, S Dhakal, B Shrestha, DK Nath, Y Kim… - Elife, 2024 - elifesciences.org
Salt (NaCl), is an essential nutrient for survival, while excessive salt can be detrimental. In
the fruit fly, Drosophila melanogaster, internal taste organs in the pharynx are critical …

The taste response to ammonia in Drosophila

R Delventhal, K Menuz, R Joseph, J Park, JS Sun… - Scientific reports, 2017 - nature.com
Ammonia is both a building block and a breakdown product of amino acids and is found
widely in the environment. The odor of ammonia is attractive to many insects, including …

Molecular and functional basis of high-salt avoidance in a blood-sucking insect

G Pontes, JM Latorre-Estivalis, ML Gutiérrez, A Cano… - IScience, 2022 - cell.com
Salts are essential nutrients required for many physiological processes, and accordingly,
their composition and concentration are tightly regulated. Taste is the ultimate sensory …

The Molecular Basis for Attractive Salt-Taste Coding in Drosophila

YV Zhang, J Ni, C Montell - Science, 2013 - science.org
Below a certain level, table salt (NaCl) is beneficial for animals, whereas excessive salt is
harmful. However, it remains unclear how low-and high-salt taste perceptions are …