The main aim of this study was to determine the functional effect of 2-methyl-thio-adenosine
diphosphate (2MeS-ADP) on vascular purinoceptors, in comparison with that of a …

1 Bovine aortic endothelial (BAE) cells contain two co‐existing receptors for extracellular
ATP, the P2Y and P2U‐purinoceptors. Here we have determined whether the proposed P2x …

The P2Y1 receptor is present in the heart, in skeletal and various smooth muscles, and in
platelets, where its activation is linked to aggregation. Adenosine 3 ', 5 '-and 2 ', 5 ' …

The P2Y1 receptor was the first of its kind to be cloned and identified as a metabotropic
receptor for adenine nucleotides (Webb et al., 1993). Since its discovery, many more P2Y …

Analysis of the P2Y family of nucleotide‐activated G‐protein‐coupled receptors has been
compromised by the lack of selective high‐affinity, high‐specific‐radioactivity radioligands …

1 The endothelium‐dependent relaxation of blood vessels induced by P2Y‐purinoceptor
activation has often been shown to involve prostacyclin and/or nitric oxide (NO) release. In …

1 BIO cells, a clonal line of rat brain capillary endothelial cells, exhibit a single P2
purinoceptor, activation of which leads to increases in free intracellular calcium. In the …

Vasorelaxation and hyperpolarization of endothelial cells by adenosine 5′‐[β‐thio]
diphosphate (ADPβS) and adenosine 5′‐[γ‐thio] triphosphate (ATPγS) were studied in rat …

The relaxant properties of the putative selective P2v agonist adenosine 5'-(2-
fluorodiphosphate)(ADP-fF) and its structural analog adenosine 5'-(2-thiodiphosphate) have …

2-Chloro-N 6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′, 5′-bisphosphate
(MRS2279) was developed previously as a selective high-affinity, non-nucleotide P2Y1 …