Both agonistic and antagonistic effects have been reported for ATP at P2Y1 purinoceptors at
micromolar ligand concentrations. These conflicting data hamper specification of the true …

The effects of ADP, ATP, 2-methylthio ATP, α, β-methylene ADP (α, βmeADP) and α,
βmeATP on smooth muscle tone and the responses to transmural nerve stimulation were …

1 Pyridoxalphosphate‐6‐azophenyl‐2′, 4′‐disulphonic acid (PPADS), a P2‐purinoceptor
antagonist, was investigated for its ability to antagonize:(1) P2X‐purinoceptor‐mediated …

The P2 receptors that mediate contraction of the rat isolated small (SPA, 200–500 μm id)
and large (LPA, 1–1.5 mm id) intrapulmonary arteries were characterized. In endothelium …

Replacement of the ribose moiety of adenosine 5′-triphosphate (ATP) with a carbocyclic
ring constrained in either the Northern (N) or Southern (S) conformation produces agonists …

Two molecularly distinct rat P2Y receptors activated equally by adenosine‐5′‐triphosphate
(ATP) and uridine‐5′‐triphosphate (UTP)(rP2Y2 and rP2Y4 receptors) were expressed in …

Extracellular dinucleotides, which act as signaling molecules in a variety of systems, may
regulate fluid homeostasis in the human lung by activation of a specific P2Y receptor …

P2 receptors are widely distributed in animal and human organisms; however, selective
antagonists of these receptors are still lacking. One of the well-known and mostly used P2 …

Interactions between different selective P2 receptor agonists have been used as tools to
identify different P2 receptor subtypes. In the present study, we examined the P2 receptor …

Abstract Background Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via
P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5' …