Among the G-protein-coupled nucleotide receptors the P2Y1 subtype can be distinguished
by its specificity for adenine nucleotides (1). ADP is a potent agonist at this receptor and its …

1 Many types of culture media contain a pH‐sensitive dye. One commonly occurring dye,
Phenol red sodium (Na+) salt, was tested for blocking activity at rat P2X1− 4 receptors …

In the search for P2-receptors modulating the stimulation-evoked entry of calcium at
processes of PC12 cells differentiated in the presence of nerve growth factor and …

1 The rat homologue of the P2Y1 receptor has been heterologously expressed in 1321N1
human astrocytoma cells and in C6 rat glioma cells. 2 As has been shown previously for the …

1 The P2‐purinoceptor subtype and the intracellular signalling mechanism (s) involved in
the rise in the free cytosolic Ca2+ concentration ([Ca2+] i) induced by ATP and analogues …

Previous studies have shown that ATP and UTP are able to stimulate phospholipase C
(PLC) and proliferation in cultured aortic smooth muscle cells. Here we set out to …

Background and purpose: Extracellular nucleotides play a crucial role in the regulation of
vascular tone and blood flow. Stimulation of endothelial cell P2Y1 receptors evokes …

ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y.
Activation of P2X receptors has traditionally been associated with the well‐characterised …

1 Diadenosine tetraphosphate (Ap4A) a dinucleotide, which is stored in secretory granules,
presents two types of high affinity binding sites in chromaffin cells. A Kd value of 8±0.65× …

The selectivities of the diadenosine polyphosphates (ApnAs, n= 2–6) at the human P2Y1,
P2Y2, P2Y4, P2Y6 and P2Y11 receptors stably expressed in 1321N1 human astrocytoma …