Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …
By conducting whole-genome sequencing and high-throughput viral integration detection …
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer
M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …
for the development of cervical cancer, however, the underlying mechanism of HPV …
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
Genomic characterization of viral integration sites in HPV‐related cancers
C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …
Multi-omics characterization of silent and productive HPV integration in cervical cancer
J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …
significant public health problem worldwide. HPV integration sites can be silent or actively …
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
K Akagi, J Li, TR Broutian, H Padilla-Nash… - Genome …, 2014 - genome.cshlp.org
Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …
papillomavirus (HPV). Here we report a striking association between HPV integration and …
Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs
A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …
Non-random integration of the HPV genome in cervical cancer
M Schmitz, C Driesch, L Jansen, IB Runnebaum… - PloS one, 2012 - journals.plos.org
HPV DNA integration into the host genome is a characteristic but not an exclusive step
during cervical carcinogenesis. It is still a matter of debate whether viral integration …
during cervical carcinogenesis. It is still a matter of debate whether viral integration …
Mechanistic signatures of HPV insertions in cervical carcinomas
A Holmes, S Lameiras, E Jeannot, Y Marie… - NPJ genomic …, 2016 - nature.com
To identify new personal biomarkers for the improved diagnosis, prognosis and biological
follow-up of human papillomavirus (HPV)-associated carcinomas, we developed a generic …
follow-up of human papillomavirus (HPV)-associated carcinomas, we developed a generic …
[HTML][HTML] HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical …
C Cao, P Hong, X Huang, D Lin, G Cao, L Wang… - Journal of genetics and …, 2020 - Elsevier
Integration of human papillomavirus (HPV) DNA into the human genome is a reputed key
driver of cervical cancer. However, the effects of HPV integration on chromatin structural …
driver of cervical cancer. However, the effects of HPV integration on chromatin structural …
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