Although glycosaminoglycans contribute to diverse physiological processes,,,, an
understanding of their molecular mechanisms has been hampered by the inability to access …

Glycosaminoglycans are sulfated biopolymers with rich chemical diversity and complex
functions in vivo, contributing to processes ranging from cell growth and neuronal …

Glycosaminoglycans (GAGs) are abundant, ubiquitous carbohydrates in biology, yet their
structural complexity has limited an understanding of their biological roles and structure …

We report the generation of chondroitin sulfate (CS) glycomimetics with tunable chemical
and biological properties. Our approach greatly simplifies the synthesis of complex …

Biological systems have evolved to utilize numerous proteins with capacity to bind
polysaccharides for the purpose of optimizing their function. A well-known subset of these …

In the central nervous system (CNS) chondroitin sulfate proteoglycans, as one of the major
barrier-forming molecules, influence cell migration patterns and axon pathfinding. By …

抄録 多硫酸化コンドロイチン硫酸 (CS) には CS-D, CS-E, CS-H および CS-K があり,
いずれもジ硫酸化あるいはトリ硫酸化二糖単位を構成単位として含むという特徴があり …

Glycosaminoglycan (GAG) biosynthesis requires numerous biosynthetic enzymes and
activated sulfate and sugar donors. Although the sequence of biosynthetic events is …

Heparan sulfate chains (HS) are initially synthesized on core proteins as linear
polysaccharides composed of glucuronic acid—N-acetylglucosamine repeating units and …

Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the
central nervous system, have the potential to interact with a wide range of growth factors and …