Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder caused by
the lack of a subsarcolemmal protein, dystrophin. We have previously shown that the …

The upregulation of endogenous utrophin in skeletal muscle may lead to a new approach to
the treatment of Duchenne muscular dystrophy (DMD). We found that injection of an E1, E3 …

Helper-dependent adenovirus vector (AdV)–mediated full-length dystrophin expression
leads to significant mitigation of the dystrophic phenotype of the mdx mouse. However …

Utrophin is a close homolog of dystrophin, the protein whose mutations cause Duchenne
muscular dystrophy (DMD). Utrophin is present at low levels in normal and dystrophic …

Rescue of dystrophic skeletal muscle in mdx and utrophin/dystrophin-deficient (dko) mouse
models by reintroduction of dystrophin has validated gene therapy as a potential therapeutic …

Ebihara, Satoru, Ghiabe-Henri Guibinga, Renald Gilbert, Josephine Nalbantoglu, Bernard
Massie, George Karpati, and Basil J. Petrof. Differential effects of dystrophin and utrophin …

Duchenne muscular dystrophy (DMD) is the most common and lethal genetic muscle
disease, caused by mutations in the dystrophin gene. No efficacious treatment is currently …

Since the identification in 1987 of the gene for Duchenne muscular dystrophy (DMD),
research on the molecular pathogenesis of muscular dystrophy has progressed extensively …

Duchenne muscular dystrophy is a lethal X-linked recessive disorder caused by mutations in
the dystrophin gene. Delivery of functionally effective levels of dystrophin to …

Duchenne muscular dystrophy (DMD) is a fatal, progressive, muscle-wasting disease
caused by defects in the dystrophin. No viral vector except the helper-dependent adenovirus …