Distinguishing tumors from normal brain cells is important but challenging in glioma surgery
due to the lack of clear interfaces between the two. The ability of label‐free third harmonic …

In brain tumor surgery, recognition of tumor boundaries is key. However, intraoperative
assessment of tumor boundaries by the neurosurgeon is difficult. Therefore, there is an …

We report the implementation of the combined third-harmonic generation (THG) and two-
photon excited fluorescence (TPEF) microscopy for label-free three-dimensional (3-D) …

The ability to distinguish and grade malignant cells during surgical procedures in a fast, non-
invasive and staining-free manner is of high importance in tumor management. To this …

Real‐time assessment of excised tissue may help to improve surgical results in breast tumor
surgeries. Here, as a step towards this purpose, the potential of second and third harmonic …

Second-harmonic generation (SHG) microscopy began to emerge as a high-resolution
optical imaging modality in the late 1990s, about 10 years after two-photon excited …

In vivo higher‐harmonic generation microscopy (HGM) performed on healthy human oral
mucosa not only provides images with a< 500 nm lateral resolution at a 280 μm penetration …

The ability to visualize neurons inside living brain tissue is a fundamental requirement in
neuroscience and neurosurgery. Especially the development of a noninvasive probe of …

Recent clinical studies on human skin indicated that in vivo multi-harmonic generation
microscopy (HGM) can achieve sub-micron resolution for histopathological analysis with a …

Third Harmonic Generation (THG) microscopy as a non‐invasive, label free imaging
methodology, allows linkage of lipid profiles with various breast cancer cells. The collected …