The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the
presence of aberrant cells, adjust its growth so that its size is in accordance with its …

Cell competition is a short-range intercellular communication, in which cells compare their
fitness with that of their neighbors and eliminate the cells with relatively lower fitness. It is …

Preimplantation development in mammals encompasses a period from fertilization to
implantation and results in formation of a blastocyst composed of three distinct cell lineages …

The striking developmental plasticity of early mammalian embryos has been known since
the classical experiments performed in the 1950s and 1960s. There are many lines of …

A fundamental question in developmental biology is whether there are mechanisms to
detect stem cells with mutations that, although not adversely affecting viability, would …

The study of animal organ size determination has provided evidence of the existence of
organ‐intrinsic mechanisms that 'sense'and adjust organ growth. Cell competition, a form of …

Abstract Specification of cell fate in the early mouse embryo involves the generation of
heterogeneities between cells in polarity, position, gene expression, and protein activity …

The first cell fate decisions during mammalian development establish tissues essential for
healthy pregnancy. The mouse has served as a valuable model for discovering pathways …

The mechanisms underlying the appearance of asymmetry between cells in the early
embryo and consequently the specification of distinct cell lineages during mammalian …

Pre-implantation mammalian development unites extreme plasticity with a robust outcome:
the formation of a blastocyst, an organised multi-layered structure ready for implantation …