Stem cells must proliferate while maintaining 'stemness'; however, much remains to be
learned about how factors that control the division of stem cells influence their identity …

Whether stem cells have unique cell cycle machineries and how they integrate with niche
interactions remains largely unknown. We identified a hypomorphic cyclin E allele WX that …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

A fundamental yet essentially unexplored question in stem cell biology is whether the stem
cell cycle has specific features. Three B-cyclins in Drosophila, Cyclins (Cyc) A, B, and B3 …

Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell
retaining stem cell identity and the other cell destined to differentiate. These cell fates are …

It is known that signaling from the germline stem cell niche is required to maintain germline
stem cell identity in Drosophila. However, it is not clear whether the germline stem-cell …

Highlights•Multiple signaling molecules regulate Drosophila ovarian germline stem cells
(GSCs).•Some signaling molecules promote GSC self-renewal, others promote …

The fluctuating CDK‐CYCLIN complex plays a general role in cell‐cycle control. Many types
of stem cells use unique features of the cell cycle to facilitate asymmetric division. However …

In this study, we uncover a role for microRNAs (miRNAs) in Drosophila germline stem cell
(GSC) maintenance. Disruption of Dicer-1 function in GSCs during adult life results in GSC …

Germline stem cells (GSCs), which can self-renew and generate differentiated progeny, are
unique stem cells in that they are solely dedicated to reproduction and transmit genetic …