Antimicrobial peptides with unusual amino acid compositions and unusual structures

N Sitaram - Current medicinal chemistry, 2006 - ingentaconnect.com
Antimicrobial peptides, which constitute an important component of innate immunity in
animal and plant kingdom, are ubiquitously distributed in nature. However, they differ widely …

Development of short antimicrobial peptides derived from host defense peptides or by combinatorial libraries

KH Lee - Current pharmaceutical design, 2002 - ingentaconnect.com
Recent increase of antibiotic-resistant pathogens demands exploration of novel
antimicrobial molecules with unexploited mechanisms. Several hundred host defense …

Identification and characterization of novel antimicrobial decapeptides generated by combinatorial chemistry

SY Hong, JE Oh, M Kwon, MJ Choi… - Antimicrobial agents …, 1998 - Am Soc Microbiol
Novel combinatorial libraries consisting of simplified amino acid sequences were designed
to screen for peptides active against the Candida albicans membrane. A novel decapeptide …

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

U Piotrowska, M Sobczak… - Chemical Biology & Drug …, 2017 - Wiley Online Library
Micro‐organism resistance is an important challenge in modern medicine due to the global
uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMP s) …

Characterization and identification of antimicrobial peptides with different functional activities

CR Chung, TR Kuo, LC Wu, TY Lee… - Briefings in …, 2020 - academic.oup.com
In recent years, antimicrobial peptides (AMPs) have become an emerging area of focus
when developing therapeutics hot spot residues of proteins are dominant against infections …

Host defense antimicrobial peptides as antibiotics: design and application strategies

B Mishra, S Reiling, D Zarena, G Wang - Current opinion in chemical …, 2017 - Elsevier
Highlights•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are
important templates for developing new antibiotics.•Both peptide discovery and application …

In Vitro and In Vivo Activities of Antimicrobial Peptides Developed Using an Amino Acid-Based Activity Prediction Method

X Wu, Z Wang, X Li, Y Fan, G He, Y Wan… - Antimicrobial agents …, 2014 - Am Soc Microbiol
To design and discover new antimicrobial peptides (AMPs) with high levels of antimicrobial
activity, a number of machine-learning methods and prediction methods have been …

Effective design of multifunctional peptides by combining compatible functions

C Diener, G Garza Ramos Martínez… - PLoS Computational …, 2016 - journals.plos.org
Multifunctionality is a common trait of many natural proteins and peptides, yet the rules to
generate such multifunctionality remain unclear. We propose that the rules defining some …

Insights into antimicrobial peptides from spiders and scorpions

X Wang, G Wang - Protein and peptide letters, 2016 - ingentaconnect.com
The venoms of spiders and scorpions contain a variety of chemical compounds.
Antimicrobial peptides (AMPs) from these organisms were first discovered in the 1990s. As …

Dual antimicrobial and anticancer activity of a novel synthetic α-helical antimicrobial peptide

B Thankappan, J Sivakumar, S Asokan… - European Journal of …, 2021 - Elsevier
Antimicrobial peptides (AMPs) are increasingly sought-after and researched antimicrobial
agents due to its desired pharmacological properties and the continuous diminishing …