Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

Cancer control by adaptive immunity involves a number of defined death,,,,,,, and clearance,,
mechanisms. However, efficient inhibition of exponential cancer growth by T cells and …

Upon the aberrant activation of oncogenes, normal cells can enter the cellular senescence
program, a state of stable cell-cycle arrest, which represents an important barrier against …

Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that
modulates the tissue microenvironment,. Physiologically, senescence serves as a tumour …

Normal cells can respond to expression of activated oncogenes by initiating cellular
senescence, a permanent state of proliferative arrest. But whether this process reflects a …

Although cancer arises from a combination of mutations in oncogenes and tumour
suppressor genes, the extent to which tumour suppressor gene loss is required for …

Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest
mechanism that acts to protect against cancer, but recent discoveries have extended its …