Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins

H Yamazaki, F Katsuoka, H Motohashi… - … and cellular biology, 2012 - Taylor & Francis
Embryogenesis is a period during which cells are exposed to dynamic changes of various
intracellular and extracellular stresses. Oxidative stress response genes are regulated by …

Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes

F Katsuoka, H Motohashi, T Ishii… - … and cellular biology, 2005 - Am Soc Microbiol
While small Maf proteins have been suggested to be essential for the Nrf2-mediated
activation of antioxidant response element (ARE)-dependent genes, the extent of their …

[HTML][HTML] The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives

MB Kannan, V Solovieva, V Blank - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
The small MAFs, MAFF, MAFG and MAFK have emerged as crucial regulators of mammalian
gene expression. Previous studies have linked small MAF function, by virtue of their …

Characterization of the murine mafF gene

K Onodera, JA Shavit, H Motohashi, F Katsuoka… - Journal of Biological …, 1999 - ASBMB
Small Maf proteins are obligatory heterodimeric partner molecules of mammalian
Cap'n'Collar proteins that together control a wide variety of eukaryotic genes. Although both …

Direct and specific functional evaluation of the Nrf2 and MafG heterodimer by introducing a tethered dimer into small Maf-deficient cells

F Katsuoka, A Otsuki, M Takahashi, S Ito… - … and Cellular Biology, 2019 - Am Soc Microbiol
ABSTRACT A group of cytoprotective genes is regulated by heterodimers composed of the
cap'n'collar (CNC) family member Nrf2 and one of the small Maf (sMaf) proteins (MafF, MafG …

Impaired megakaryopoiesis and behavioral defects inmafG-null mutant mice

JA Shavit, H Motohashi, K Onodera… - Genes & …, 1998 - genesdev.cshlp.org
The small Maf proteins (MafG, MafK, and MafF), which serve as heterodimeric partner
molecules of CNC family proteins for binding in vitro to MARE sites, have been implicated in …

Small Maf deficiency recapitulates the liver phenotypes of Nrf1‐and Nrf2‐deficient mice

F Katsuoka, H Yamazaki, M Yamamoto - Genes to Cells, 2016 - Wiley Online Library
Nrf1 and Nrf2 (NF‐E2‐related factors 1 and 2, respectively) are transcription factors that
belong to the Cap'n'collar (CNC) family and play critical roles in various tissues, including …

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

H Motohashi, T O'Connor, F Katsuoka, JD Engel… - Gene, 2002 - Elsevier
Recent progress in the analysis of transcriptional regulation has revealed the presence of an
exquisite functional network comprising the Maf and Cap'n'collar (CNC) families of …

Nrf2 transcriptionally activates the mafG gene through an antioxidant response element

F Katsuoka, H Motohashi, JD Engel… - Journal of Biological …, 2005 - ASBMB
Nrf2 accumulates in nuclei upon exposure to oxidative stress, heterodimerizes with a small
Maf protein, and activates the transcription of stress target genes through antioxidant …

The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents: ROLE FOR Nrf1 IN γ-gcs L AND …

M Kwong, YW Kan, JY Chan - Journal of Biological Chemistry, 1999 - ASBMB
Nrf1 is a member of the CNC-basic leucine zipper (CNC-bZIP) family of transcription factors.
CNC bZIP factors, together with small Maf proteins, bind as heterodimers to the NF-E2/AP-1 …