Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening
YQ Song, XQ Guan, ZM Weng, YQ Wang… - International journal of …, 2019 - Elsevier
Abstract Human carboxylesterase 2 (CES2A), one of the most abundant hydrolases
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …
distributed in human small intestine and colon, play key roles in the hydrolysis of a wide …
Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
YQ Song, RJ He, D Pu, XQ Guan, JH Shi… - Frontiers in …, 2021 - frontiersin.org
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2
YS Zhao, XK Qian, XQ Guan, PF Song, YQ Song… - Bioorganic …, 2020 - Elsevier
Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
PF Song, YD Zhu, HY Ma, YN Wang, DD Wang… - Fitoterapia, 2019 - Elsevier
Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays
YQ Song, XQ Guan, ZM Weng, JL Liu, J Chen… - Food & function, 2021 - pubs.rsc.org
Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …
Carboxylesterase inhibitors: an update
LW Zou, Q Jin, DD Wang, QK Qian… - Current Medicinal …, 2018 - ingentaconnect.com
Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2
Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Functional study of carboxylesterase 1 protein isoforms
Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in
hydrolytic biotransformation of numerous medications. Considerable interindividual …
hydrolytic biotransformation of numerous medications. Considerable interindividual …
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1
Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …
The crystal structure of mouse ces2c, a potential ortholog of human CES2, shows structural similarities in substrate regulation and product release to human CES1
H Eisner, L Riegler-Berket, CFR Gamez… - International Journal of …, 2022 - mdpi.com
Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with
respect to their hydrolytic function on (pro) drugs, whereas their physiological role in lipid …
respect to their hydrolytic function on (pro) drugs, whereas their physiological role in lipid …
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