COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib
S Grösch, I Tegeder, E Niederberger… - The FASEB …, 2001 - Wiley Online Library
The regular use of various nonsteroidal anti‐inflammatory drugs (NSAIDs) was shown to
decrease the incidence of colorectal cancer. This effect is thought to be caused …
decrease the incidence of colorectal cancer. This effect is thought to be caused …
Cyclooxygenase-2 (COX-2)-dependent and-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
TJ Maier, K Schilling, R Schmidt, G Geisslinger… - Biochemical …, 2004 - Elsevier
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is the only non-steroidal anti-
inflammatory drug so far which has been approved by the FDA for adjuvant treatment of …
inflammatory drug so far which has been approved by the FDA for adjuvant treatment of …
Selective cyclooxygenase‐2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells
R Yamazaki, N Kusunoki, T Matsuzaki… - FEBS …, 2002 - Wiley Online Library
Although the influence of selective cyclooxygenase (COX)‐2 inhibitors on the proliferation of
colon adenocarcinoma cells have been the subject of much investigation, relatively little …
colon adenocarcinoma cells have been the subject of much investigation, relatively little …
Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis
BS Reddy, Y Hirose, R Lubet, V Steele, G Kelloff… - Cancer research, 2000 - AACR
Epidemiological observations and laboratory research have suggested that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …
Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug …
DJ Elder, DE Halton, A Hague, C Paraskeva - Clinical cancer research: an …, 1997 - AACR
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid to prostaglandin H2.
The inducible isoform, COX-2, promotes colorectal tumorigenesis, and nonsteroidal anti …
The inducible isoform, COX-2, promotes colorectal tumorigenesis, and nonsteroidal anti …
Celecoxib Prevents Tumor Growth in Vivo without Toxicity to Normal Gut: Lack of Correlation between in Vitro and in Vivo Models
CS Williams, AJM Watson, H Sheng, R Helou, J Shao… - Cancer research, 2000 - AACR
Nonsteroidal anti-inflammatory drugs have potential for use in the prevention and/or
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action
ML Smith, G Hawcroft, MA Hull - European journal of cancer, 2000 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and induce apoptosis in
human colorectal cancer cells in vitro. It remains unclear whether individual NSAIDs act by …
human colorectal cancer cells in vitro. It remains unclear whether individual NSAIDs act by …
Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective cyclooxygenase-2 inhibitor, in human head and neck carcinoma cell …
S Hashitani, M Urade, N Nishimura… - International …, 2003 - spandidos-publications.com
Colorectal carcinomas are well known to highly express COX-2 and their growth is markedly
inhibited by COX-2 inhibitors, but little is known about head and neck carcinomas. In this …
inhibited by COX-2 inhibitors, but little is known about head and neck carcinomas. In this …
Role of cyclooxygenase-2 in colorectal cancer
FA Sinicrope, S Gill - Cancer and Metastasis Reviews, 2004 - Springer
Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …
The MEK/ERK pathway mediates COX‐2‐selective NSAID‐induced apoptosis and induced COX‐2 protein expression in colorectal carcinoma cells
DJE Elder, DE Halton, LC Playle… - International journal of …, 2002 - Wiley Online Library
Nonsteroidal antiinflammatory drugs (NSAIDs) can prevent colorectal tumorigenesis in
humans and in rodents. In vitro and in vivo studies indicate that one of their principal …
humans and in rodents. In vitro and in vivo studies indicate that one of their principal …