Growth differentiation factor‐15 and the risk of cardiovascular diseases and all‐cause mortality: A meta‐analysis of prospective studies

S Xie, L Lu, L Liu - Clinical cardiology, 2019 - Wiley Online Library
Background and Aim Previous studies have documented that the association between
growth differentiation factor‐15 (GDF‐15) the risk of patients with cardiovascular diseases …

Growth differentiation factor-15 (GDF-15) is a biomarker of muscle wasting and renal dysfunction in preoperative cardiovascular surgery patients

T Nakajima, I Shibasaki, T Sawaguchi… - Journal of clinical …, 2019 - mdpi.com
Frailty and sarcopenia increase the risk of complications and mortality when invasive
treatment such as cardiac surgery is performed. Growth differentiation factor-15 (GDF-15) …

Elevated plasma growth and differentiation factor 15 is associated with slower gait speed and lower physical performance in healthy community-dwelling adults

RD Semba, M Gonzalez-Freire, T Tanaka… - The Journals of …, 2020 - academic.oup.com
Background Growth and differentiation factor 15 (GDF-15) has been associated with obesity,
muscle wasting, and cachexia. The receptor for GDF-15 was recently identified in the …

Growth‐differentiation factor‐15 improves reclassification for the diagnosis of heart failure with normal ejection fraction in morbid obesity

A Baessler, C Strack, E Rousseva… - European journal of …, 2012 - Wiley Online Library
Aims This study aimed to examine the incremental value of growth‐differentiation factor‐15
(GDF‐15) to N‐terminal pro brain natriuretic hormone (NT‐proBNP) levels for the diagnosis …

GDF-15 as a weight watcher for diabetic and non-diabetic people treated with metformin

J Ouyang, S Isnard, J Lin, B Fombuena… - Frontiers in …, 2020 - frontiersin.org
Weight gain and obesity are global health concerns contributing to morbidity with increased
risks of cardiovascular disease, diabetes, liver steatohepatitis and cancer. Pharmacological …

GDF-15 in pulmonary and critical care medicine

FM Verhamme, CM Freeman, GG Brusselle… - American journal of …, 2019 - atsjournals.org
GDF-15 (growth differentiation factor 15) acts both as a stress-induced cytokine with diverse
actions at different body sites and as a cell-autonomous regulator linked to cellular …

Growth differentiation factor-15, a novel biomarker related with disease severity in patients with hypertrophic cardiomyopathy

S Montoro-García, D Hernández-Romero… - European journal of …, 2012 - Elsevier
BACKGROUND: The growth differentiation factor 15 (GDF-15) has been shown up-
regulated in stress conditions and to have regulatory actions in myocyte hypertrophy. We …

Serum growth differentiation factor 15 level is associated with muscle strength and lower extremity function in older patients with cardiometabolic disease

K Oba, J Ishikawa, Y Tamura, Y Fujita… - Geriatrics & …, 2020 - Wiley Online Library
Aims Sarcopenia is a serious problem because of its poor prognosis. Growth differentiation
factor 15 (GDF15) is associated with mitochondrial dysfunction, inflammation, insulin …

The clinical impact of growth differentiation factor-15 in heart disease: A 2019 update

M Arkoumani, N Papadopoulou-Marketou… - Critical Reviews in …, 2020 - Taylor & Francis
Abstract Growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory
cytokine-1 (MIC-1) or non-steroidal anti-inflammatory drug-activated gene (NAG-1) has been …

The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a …

SL Au Yeung, S Luo, CM Schooling - Diabetologia, 2019 - Springer
Aims/hypothesis Growth differentiation factor 15 (GDF-15), a suggested biomarker for
metformin use, may explain the potential cardioprotective and anti-cancer properties of …