The process of metastasis is complex. In breast cancer, there are frequently long time
intervals between cells leaving the primary tumour and growth of overt metastases …

Abstract Background The Wnt family of secreted proteins is implicated in the regulation of
cell fate during development, as well as in cell proliferation, morphology, and migration …

Increasing evidence shows that cancer cells can disseminate from early evolved primary
lesions much earlier than the classical metastasis models predicted. Here, we reveal at a …

Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted
glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to …

Elevated coexpression of colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1,
correlates with invasiveness and poor prognosis of a variety of epithelial tumors (Kacinski …

Aberrant activation of the Wnt signaling pathway plays an important role in the development
of solid tumors such as breast and colon cancer. Secreted Frizzled-related protein 1 …

Background Transforming growth factor (TGF)-β plays a dual role during mammary gland
development and tumorigenesis and has been shown to stimulate epithelial-mesenchymal …

Arising from: RN Kaplan et al. Nature438, 820–827 (2005) 10.1038/nature04186; Kaplan et
al. reply Molecules such as vascular endothelial growth factor (VEGF) or placental growth …

Cancer metastasis requires that primary tumour cells evolve the capacity to intravasate into
the lymphatic system or vasculature, and extravasate into and colonize secondary sites …

Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the
molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism …