Amorphous solid dispersions: utilization and challenges in drug discovery and development

Y He, C Ho - Journal of pharmaceutical sciences, 2015 - Elsevier
Amorphous solid dispersion (ASD) can accelerate a project by improving dissolution rate
and solubility, offering dose escalation flexibility and excipient acceptance for toxicology …

[HTML][HTML] Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization

S Tambe, D Jain, SK Meruva, G Rongala, A Juluri… - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

[HTML][HTML] Amorphous solid dispersions (ASDs): The influence of material properties, manufacturing processes and analytical technologies in drug product development

R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Characterization of amorphous solid dispersions: An update

X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …

Characterization of amorphous solid dispersions

X Liu, X Feng, RO Williams, F Zhang - Journal of Pharmaceutical …, 2018 - Springer
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …

Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

P Pandi, R Bulusu, N Kommineni, W Khan… - International journal of …, 2020 - Elsevier
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Amorphous solid dispersions: Utilization and challenges in preclinical drug development within AstraZeneca

AB Anane-Adjei, E Jacobs, SC Nash, S Askin… - International Journal of …, 2022 - Elsevier
The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

[图书][B] Pharmaceutical amorphous solid dispersions

A Newman - 2015 - books.google.com
Providing a roadmap from early to late stages of drug development, this book overviews
amorphous solid dispersion technology–a leading platform to deliver poorly water soluble …

The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate

G Van den Mooter - Drug Discovery Today: Technologies, 2012 - Elsevier
The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …