Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …

Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

The alarming numbers of poorly soluble discovery compounds have centered the efforts
towards finding strategies to improve the solubility. One of the attractive approaches to …

Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …

Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

The use of amorphous solid dispersions to improve the bioavailability of active ingredients
from the BCS II and IV classifications continues to gain interest in the pharmaceutical …

Modern drug discovery tools have biased towards compounds with poor aqueous solubility
even though the importance of drug-like properties has long been recognized [1], and the …

The idea of writing this book was triggered by the development of ASD utilizing
microprecipitated bulk powder (MBP) technology at Hoffmann-La Roche and the successful …