Although a heterozygous deficiency of either complement component C4A or C4B is
common, and each has a frequency of∼ 20% in a Caucasian population, complete …

The disease course of a complete C4-deficient patient in the US was followed for 18 years.
The patient experienced multiple episodes of infection, and he was diagnosed with systemic …

Complete deficiency of the complement C4A isotype is a known genetic risk factor for
systemic lupus erythematosus (SLE). The disease phenotype of C4A-deficient patients has …

Complement C6 homozygous deficiency (C6D) has been rarely observed in Caucasians but
was reported at higher prevalence among African-Americans. We report on the molecular …

Genetic deficiency of the second component of complement (C2) is the most common
complement-deficiency state among Western Europeans and is frequently associated with …

Complete absence of C1r and almost complete absence of C1s were found in 4 of 8 living
siblings. Two of the 4 suffer from a syndrome that combines discoid lupus erythematosus …

The complement protein C4, encoded by two genes (C4A and C4B) on chromosome 6p, is
the most polymorphic among the MHC III gene products. We investigated the molecular …

Abstract Complement C7 deficiency (C7D) is associated frequently with recurrent bacterial
infections, especially meningitis caused by Neisseria meningitidis. We report in this work the …

A case of inherited homozygous complement C3 deficiency (C3D) in a patient with systemic
lupus erythematosus (SLE) and the molecular basis for this deficiency are reported. A 22 …

Deficiencies in terminal complement components, including the component C7, are
uncommon and associated with an increased risk of recurrent systemic neisserial infection …