Obesity affects a growing fraction of the population and is a risk factor for type 2 diabetes
and cardiovascular disease. Even in the absence of hypertension and coronary artery …

Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial isozyme of the heart involved in the
metabolism of toxic aldehydes produced from oxidative stress. We hypothesized that …

AMP-activated protein kinase alpha 2 (AMPKα2) regulates energy metabolism, protein
synthesis, and glucolipid metabolism myocardial cells. Ketone bodies produced by fatty acid …

Diabetes is a well-known risk factor for heart failure. Diabetic heart damage is closely related
to mitochondrial dysfunction and increased ROS generation. However, clinical trials have …

Obesity and related metabolic conditions such as type 2 diabetes mellitus (T2DM) are
increasing in prevalence in the United States. While restricting caloric intake or increasing …

Long chain saturated β-hydroxy fatty acid content and oxidative metabolism were studied in
hearts of diabetic mice (C57BL/KsJ db/db) with a progressive cardiomy-opathy at intervals of …

5′-adenosine monophosphate-activated protein kinase (AMPK) is considered central in
regulation of energy status and substrate utilization within cells. In heart failure the energetic …

AMP deaminase (AMPD) plays a crucial role in adenine nucleotide metabolism. Recently
we found that upregulated AMPD activity is associated with ATP depletion and contractile …

Objective Throughout the last decade, interest has intensified in intermittent fasting,
ketogenic diets, and exogenous ketone therapies as prospective health-promoting …

To elucidate the mechanism underlying diabetes caused by mitochondrial gene mutations,
we created a model by applying 0.4 μg/ml ethidium bromide (EtBr) to the murine pancreatic …