SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency

Y Li, MC Choudhary, J Regan, J Boucau… - Science translational …, 2024 - science.org
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

A Alrubayyi, E Gea-Mallorquí, E Touizer… - Nature …, 2021 - nature.com
There is an urgent need to understand the nature of immune responses against SARS-CoV-
2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that …

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

T Nkosi, C Chasara, AO Papadopoulos, TL Nguni… - Elife, 2022 - elifesciences.org
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease,
but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the …

Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults

HR Wagstaffe, RS Thwaites, A Reynaldi, JK Sidhu… - Science …, 2024 - science.org
Human infection challenge permits in-depth, early, and pre-symptomatic characterization of
the immune response, enabling the identification of factors that are important for viral …

Early virus clearance and delayed antibody response in a case of coronavirus disease 2019 (COVID-19) with a history of coinfection with human immunodeficiency …

J Zhao, X Liao, H Wang, L Wei, M Xing… - Clinical Infectious …, 2020 - academic.oup.com
The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease …

[HTML][HTML] COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

A Bonifacius, S Tischer-Zimmermann, AC Dragon… - Immunity, 2021 - cell.com
Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and
correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its …

Persistence of antibody and cellular immune responses in coronavirus disease 2019 patients over nine months after infection

L Yao, GL Wang, Y Shen, ZY Wang… - The Journal of …, 2021 - academic.oup.com
Background The duration of humoral and T and B cell response after the infection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. Methods We …

Transmission and infectious SARS-CoV-2 shedding kinetics in vaccinated and unvaccinated individuals

J Jung, JY Kim, H Park, S Park, JS Lim… - JAMA network …, 2022 - jamanetwork.com
Importance Data are limited on whether patients with breakthrough COVID-19 infection have
the potential to significantly contribute to the spread of SARS-CoV-2. Objective To compare …

Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection

MJ Peluso, MA Spinelli, TM Deveau, CA Forman… - Aids, 2022 - journals.lww.com
Background: Limited data are available on the long-term clinical and immunologic
consequences of SARS-CoV-2 infection in people with HIV (PWH). Methods: We measured …

Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes

E Pradenas, B Trinité, V Urrea, S Marfil, C Ávila-Nieto… - Med, 2021 - cell.com
Background Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone
for public health control of the pandemic and vaccine development. However, current …