Brain signaling is a crucial event for the body to mount an appropriate response to invading
microorganisms. Pro-inflammatory cytokines are released from infected tissues and reach …

Septic encephalopathy is a frequent complication of the sepsis syndrome, with no therapies
available that can prevent the associated neurological dysfunction in humans. It is caused …

Sepsis occurs when a systemic infection induces an uncontrolled inflammatory response
that results in generalized organ dysfunction. The exacerbated peripheral inflammation can …

Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host immune
response to eliminate an infection. After the host immune response is activated, a complex …

Frequently underestimated, encephalopathy or delirium are common neurological
manifestations associated with sepsis. Brain dysfunction occurs in up to 80% of cases and is …

On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side,
brain dysfunction may actively contribute to the pathogenesis of sepsis. The current review …

Systemic infection is often revealed by or associated with brain dysfunction, which is
characterized by alteration of consciousness, ranging from delirium to coma, seizure or focal …

Several mechanisms are associated with brain dysfunction during sepsis; one of the most
important are activation of microglia and astrocytes. Activation of glial cells induces changes …

Background Septic encephalopathy is a severe brain dysfunction caused by systemic
inflammation in the absence of direct brain infection. Changes in cerebral blood flow …

During severe sepsis several immunological defence mechanisms initiate a cascade of
inflammatory events leading to multi-organ failure including septic encephalopathy and …