[HTML][HTML] Isatin-hydrazones with multiple Receptor Tyrosine Kinases (RTKs) inhibitory activity and in-silico binding mechanism
Recently, we have reported a series of isatin hydrazone, two of them, namely, 3-((2, 6-
dichlorobenzylidene) hydrazono) indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene) …
dichlorobenzylidene) hydrazono) indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene) …
[HTML][HTML] A series of isatin-hydrazones with cytotoxic activity and CDK2 kinase inhibitory activity: a potential type II ATP competitive inhibitor
HS Al-Salem, M Arifuzzaman, HM Alkahtani… - Molecules, 2020 - mdpi.com
Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …
Investigation of Newly Synthesized Fluorinated Isatin-Hydrazones by In Vitro Antiproliferative Activity, Molecular Docking, ADME Analysis, and e-Pharmacophore …
In this study, we investigated the in vitro antiproliferative activities and performed
computational studies of newly synthesized fluorinated isatin-hydrazones. The chemical …
computational studies of newly synthesized fluorinated isatin-hydrazones. The chemical …
Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono) indolin-2-ones as anticancer agents
HE Dweedar, H Mahrous, HS Ibrahim… - European Journal of …, 2014 - Elsevier
The docking studies on CDK2 and GSK-3β inspired us to synthesis a series of indoline-2, 3-
dione hydrazones 10a–l. Treatment of indoline-2, 3-dione derivatives 7a–d with hydrazine …
dione hydrazones 10a–l. Treatment of indoline-2, 3-dione derivatives 7a–d with hydrazine …
Synthesis, biological activity and docking study of some new isatin Schiff base derivatives
J Azizian, MK Mohammadi, O Firuzi… - Medicinal Chemistry …, 2012 - Springer
A set of novel Schiff bases of isatin were synthesized and characterized by reaction of isatin
with various aromatic or heterocyclic primary amines. Cytotoxic activities for some of the …
with various aromatic or heterocyclic primary amines. Cytotoxic activities for some of the …
Novel hydrazone‐isatin derivatives as potential EGFR inhibitors: Synthesis and in vitro pharmacological profiling
MF Ahmed, R El‐Haggar, AH Almalki… - Archiv der …, 2023 - Wiley Online Library
Merging isatin and arylhydrazone moieties constitutes an efficient strategy to access new
potential anticancer derivatives. Consequently, 14 hydrazone‐isatin derivatives were …
potential anticancer derivatives. Consequently, 14 hydrazone‐isatin derivatives were …
Discovery of 3, 6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico …
A Sabt, WM Eldehna, T Al-Warhi… - Journal of Enzyme …, 2020 - Taylor & Francis
Human health in the current medical era is facing numerous challenges, especially cancer.
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment
P Shirvani, N Fayyazi, S Van Belle, Z Debyser… - Bioorganic & Medicinal …, 2022 - Elsevier
Keeping in view the pharmacological properties of indolinones as promising scaffold as
kinase inhibitors, herein, a novel series of 3-hydrazonoindolin-2-one derivatives bearing 3 …
kinase inhibitors, herein, a novel series of 3-hydrazonoindolin-2-one derivatives bearing 3 …
Assessment of iridoids and their similar structures as antineoplastic drugs by in silico approach
P Neupane, J Adhikari Subin… - Journal of Biomolecular …, 2024 - Taylor & Francis
Iridoids commonly found in plants as secondary metabolites have been reported to possess
significant biological activities such as anticancer, antioxidant, hypoglycemic, antimicrobial …
significant biological activities such as anticancer, antioxidant, hypoglycemic, antimicrobial …
Imidazo [1, 2-a] quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies
Z Hasanvand, TO Bakhshaiesh, F Peytam… - Bioorganic …, 2023 - Elsevier
Tyrosine protein kinases (TKs) have been proved to play substantial roles on many cellular
processes and their overexpression tend to be found in various types of cancers. Therefore …
processes and their overexpression tend to be found in various types of cancers. Therefore …