When injected at tracer levels into the blood, radiogallium as 67 Ga-citrate binds to, and is
transported to the site of the tumor by, transferrin. The process by which transferrin-bound …

When injected at tracer levels into the blood, radiogallium binds to plasma transferrin and is
transported to the tumor tissue. The mechanism, however, by which this transferrin-bound …

Human melanoma cells were incubated with 67 Ga-citrate, a mixture of 67 Ga-citrate and
transferrin, 67 Ga-transferrin and 67 Ga-transferrin-125 I. It was found that there was a …

In certain animal tumor systems, transferrin appears to play a key role in the cellular uptake
of radiogallium. This process is mediated by a transferrin receptor which is present on tumor …

The mechanism of radiogallium uptake into tumor in vivo has been investigated using the
canine transmissible venereal tumor (TVT) as a model. The blood clearance and uptake in …

Different gallium-transferrin-anion complexes (nitrilotriacetate, maleate, malonate and
oxalate) were investigated to determine the effect of such anion complexes on gallium-67 …

In order to evaluate the mechanisms which facilitate the transfer of 67 Ga from transferrin in
plasma to intracellular binding sites, lactoferrin, a glycoprotein with high affinity for 67 Ga …

The uptake of 67 Ga-citrate in the tissues of the mouse and rat and in two mouse tumours,
S180 and PC6, has been measured and shown to be independent of the citrate …

As a crucial step toward the understanding of the tumor localization of gallium, we have re-
investigated its binding and transport in blood. The studies were performed in vivo by …

The large number of publications dealing with biokinetics, metabolism and factors
influencing tissue uptake of 67 Ga-citrate could not clarify the mechanism responsible for the …