Diabetic peripheral neuropathy (DPN) refers to the development of peripheral nerve
dysfunction in patients with diabetes when other causes are excluded. Diabetic distal …

OBJECTIVE Reactive oxygen species (ROS) are pro-oxidant factors in distal
neurodegeneration in diabetes. We tested the hypothesis that sensory neurons exposed to …

OBJECTIVE Impairments in mitochondrial function have been proposed to play a role in the
etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial …

Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of
peripheral nervous system with high energy requirement. The adenosine monophosphate …

Emerging data establish dyslipidemia as a significant contributor to the development of
diabetic neuropathy. In this review, we discuss how separate metabolic imbalances …

Diabetic-induced peripheral neuropathy (DPN) is a highly complex and frequent diabetic
late complication, which is manifested by prolonged hyperglycemia. However, the molecular …

We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion (DRG)
neurons using immunohistochemical and electrophysiologic techniques for evidence of …

OBJECTIVE—Peripheral neuropathy associated with type 2 diabetes (DPN) is not widely
modeled. We describe unique features of DPN in type 2 diabetic Zucker diabetic fatty (ZDF) …

High glucose levels in the peripheral nervous system (PNS) have been implicated in the
pathogenesis of diabetic neuropathy (DN). However, our understanding of the molecular …

Diabetes causes mitochondrial dysfunction in sensory neurons that may contribute to
peripheral neuropathy. Ciliary neurotrophic factor (CNTF) promotes sensory neuron survival …