How does glucose generate oxidative stress in peripheral nerve?

IG Obrosova - International review of neurobiology, 2002 - Elsevier
Diabetes-associated oxidative stress is clearly manifest in peripheral nerve, dorsal root, and
sympathetic ganglia of the peripheral nervous system and endothelial cells and is implicated …

Transcriptional Profiling of Diabetic Neuropathy in the BKS db/db Mouse: A Model of Type 2 Diabetes

M Pande, J Hur, Y Hong, C Backus, JM Hayes… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE A better understanding of the molecular mechanisms underlying the
development and progression of diabetic neuropathy (DN) is essential for the design of …

Diabetic neuropathy and the sensory neuron: new aspects of pathogenesis and their treatment implications

M Kobayashi, DW Zochodne - Journal of diabetes investigation, 2018 - Wiley Online Library
Diabetic polyneuropathy (DPN) continues to be generally considered as a “microvascular”
complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular …

Protection from diabetes-induced peripheral sensory neuropathy—A role for elevated glyoxalase I?

MM Jack, JM Ryals, DE Wright - Experimental neurology, 2012 - Elsevier
Diabetic neuropathy is a common complication of diabetes mellitus with over half of all
patients developing neuropathy symptoms due to sensory nerve damage. Diabetes-induced …

New perspectives in diabetic neuropathy

SA Eid, AE Rumora, B Beirowski, DL Bennett, J Hur… - Neuron, 2023 - cell.com
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Diabetic neuropathies: components of etiology

DR Tomlinson, NJ Gardiner - Journal of the peripheral Nervous …, 2008 - Wiley Online Library
This review examines the putative role of glucose in the etiology of diabetic neuropathies.
Excessive glucose generates several secondary metabolic anomalies—principally oxidative …

Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?

KL Farmer, C Li, RT Dobrowsky - Pharmacological reviews, 2012 - ASPET
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is
associated with axonal atrophy, demyelination, blunted regenerative potential, and loss of …

Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms

PS Van Dam, MA Cotter, B Bravenboer… - European journal of …, 2013 - Elsevier
Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people
with diabetes, and are major risk factors for foot ulceration and amputation. The aetiology is …

Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies

M Kaur, S Mishra, P Swarnkar, P Patel, BD Kurmi… - Biochemical …, 2023 - Elsevier
Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …

Neuropathology and pathogenesis of diabetic autonomic neuropathy

RE Schmidt - International review of neurobiology, 2002 - Elsevier
Autonomic neuropathy is a significant complication of diabetes resulting in increased patient
morbidity and mortality. A number of studies, which have shown correspondence between …