Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three
main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress …

Progress in developing treatments for diabetic neuropathy is slowed by our limited
understanding of how disturbances in metabolic substrates–glucose and fatty acids …

Diabetic neuropathy is a heterogeneous group of disorders with extremely complex
pathophysiology and affects both somatic and autonomic components of the nervous …

Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy,
but the mechanisms remain unidentified. Here we provide evidence that poly (ADP-ribose) …

Diabetes is the most prevalent metabolic disorder in the United States, and between 50%
and 70% of diabetic patients suffer from diabetes-induced neuropathy. Yet our current …

Diabetic neuropathy is one of the clinical syndromes characterized by pain and substantial
morbidity primarily due to a lesion of the somatosensory nervous system. The burden of …

The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …

The World Health Organization (WHO) predicts there will be 300 million people world-wide
with diabetes mellitus by 2025. Currently it is estimated that there are 20 and 60 million …

Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration in
diabetes complications. The aim of this study was to determine whether deficits in insulin …

Sensory neurons in diabetes may be primarily targeted by diabetes and their involvement
may account for prominent sensory loss and pain in diabetic patients. Previous studies …